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要旨 患者は80歳代,女性.検診2次検査で大腸内視鏡検査を受け,下部直腸に30×22mmの0-Is+IIa型病変を指摘された.0-Is型領域は結節集簇様病変で,NBI拡大内視鏡観察にて,広島分類C1・佐野分類IIIA,pit pattern診断では,IV型pitを基調としたVI型軽度不整pit patternであった.0-Is型隆起周囲には,絨毛状構造を呈する0-IIa型領域と血管透見が保たれている丈の低い0-IIa型領域が拡がっていた.丈の低い0-IIa型領域の表面構造は,マスクメロン様の網目状を呈する特異な形態で,不整腺管構造としてVI型pit patternと判断した.腺腫内癌と診断し,Hybrid-ESD法で網目状0-IIa型領域も含めて一括切除を行った.病理組織診断は,0-Is型,0-IIa型領域ともに,異型度の異なる細胞が,領域性を持たずに不規則に混在しながら,乳頭状ないし絨毛状構造を呈しており,全体として粘膜内に限局した乳頭腺癌(pap>tub1)と診断した.組織学的に網目状0-IIa型領域は,乳頭腺癌がまばらな腺管の表層を置換性に発育した,0-Is型隆起から側方に進展した病変であると考えられた.
An 80-year-old female visited our hospital to undergo colonoscopy as a further examination of positive fecal occult blood test. Colonoscopy revealed a sessile protruded lesion with a superficial slightly elevated lesion(0-Is+IIa, with a diameter of 30mm×22mm)in the lower rectum. The 0-Is part was nodule-aggregated lesion identified as a Hiroshima classification type C1/Sano classification type III A by the NBI(narrow band imaging)magnifying observation. This part showed a type VI pit pattern with low-grade irregularity based on a type IV pit by magnifying observation under indigocarmine. The 0-IIa part had a muskmelon-like unique surface pattern with few microvessels, and surface pattern did not match a conventional pit pattern, so we could not classify it except as a type VI pit pattern. We diagnosed it as an intramucosal adenocarcinoma with adenoma, and we performed an en bloc resection to include the 0-IIa part by Hybrid-ESD(endoscopic submucosal dissection).
Histopathological examination revealed that both the 0-Is part and the 0-IIa part consisted of cells with various grade atypia which were intermingled irregularly. Thus, we diagnosed the cells as intramucosal papillary adenocarcinoma(pap>tub1). We speculated that the 0-IIa part which had a muskmelon-like unique surface pattern was the lesion that had extended laterally with replacing a surface layer around the 0-Is papillary adenocarcinoma.
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