Stomach and Intestine(Tokyo) Volume 47, Issue 11 (October 2012)

Alteration of Gastric Atrophy and Intestinal Metaplasia in the Long-term after Helicobacter pylori Eradication Therapy Kazunari Murakami 1 , Masaaki Kodama 1 , Yoshihumi Nakagawa 1 , Kazuhiro Mizukami 1 , Tadayoshi Okimoto 1 , Toshio Fujioka 1 1Department of Gastroenterology, Faculty of Medicine, Oita University, Oita, Japan Keyword: H. pylori , 除菌後経過 , 萎縮 , 腸上皮化生 , 胃癌予防 pp.1657-1662
Published Date 2012/10/25
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 Atrophic gastritis and IM(intestinal metaplasia)are well known as precancerous lesions of gastric cancer. The present study evaluated the gastric mucosa for 10years after H. pylori eradication. Patients with successful eradication underwent follow-up endoscopic examination every year prospectively. Biopsy specimens were taken from five points of the stomach as recommended by the updated Sydney system. The courses of 30patients were able to be observed every year for 10years after successful eradication. Atrophy score at all five points were significantly reduced half a year to 6years after eradication. IM score of the lesser curvature of the corpus continued decreasing gradually and showed a significant decrease 6years after. Within 10years after H. pylori eradication, atrophy at all sites and IM in the lesser curvature of the corpus gradually and significantly decreased. These results suggest that the improvement of gastric atrophy and IM might have some kind of association with the reduction of gastric cancer occurrence.

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47巻11号 (2012年10月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院