Japanese

A Case of Primary Colon Cancer Composed of Invasive Micropapillary Carcinoma Showing Submucosal Tumor-like Appearance Hajime Takisawa 1 , Eriko So 1 , Takeshi Nakajima 1 , Takahisa Matsuda 1 , Yutaka Saito 1 , Ryoji Kushima 2 1Endoscopy Division, National Cancer Center Hospital, Tokyo 2Division of Pathology, National Cancer Center Hospital, Tokyo Keyword: 早期大腸癌 , 浸潤性微小乳頭癌 , invasive micropapillary carcinoma pp.1293-1300
Published Date 2012/7/25
DOI https://doi.org/10.11477/mf.1403113554
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 A 40-year-old man without any symptom underwent colonoscopy for a medical checkup. A small protruded lesion showing submucosal tumor-like appearance with depressed area on the top of tumor was detected in the ascending colon. The tumor size was 10mm in diameter. Magnifying view suggested the tumor had invaded into the deep submucosal layer in the depressed area. Laparoscopic-assisted right hemicolectomy was performed. Histologically, the tumor was predominantly composed of small papillary tumor cell clusters floating in clear spaces resembling lymphatic channels. Immunohistochemically, epithelial membranous antigen was expressed at the stroma-facing surface of the cells, showing a characteristic“inside-out growth pattern”. Therefore, this tumor was diagnosed as invasive micropapillary carcinoma(IMPC). IMPCs have been reported to be a poorly prognostic tumor with a high incidence of lymphatic invasion and lymph node metastasis. The patient has enjoyed good health for one year without recurrence.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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