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Small Bowel Neoplasia in Familial Adenomatous Polyposis and Lynch Syndrome Patients Takeshi Nakajima 1 , Minori Matsumoto 1 , Taku Sakamoto 1 , Shigeki Sekine 2 , Kokichi Sugano 3 , Teruhiko Yoshida 3 , Takahisa Matsuda 1 , Yasuo Kakugawa 1 , Yosuke Otake 1 , Eriko So 1 , Masayoshi Yamada 1 , Tomoko Okamoto 1 , Hiroyuki Takamaru 1 , Hirokazu Taniguchi 4 , Ryoji Kushima 4 , Yutaka Saito 1 1Endoscopy Division, National Cancer Center Hospital, Tokyo 2Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 3Department of General Internal Medicine, National Cancer Center Hospital, Tokyo 4Department of Pathology, National Cancer Center Hospital, Tokyo Keyword: 遺伝性大腸癌 , 家族性大腸腺腫症 , familial adenomatous polyposis , FAP , Lynch症候群 , リンチ症候群 , HNPCC , hereditary non-polyposis colorectal cancer , 小腸癌 pp.1487-1494
Published Date 2013/9/25
DOI https://doi.org/10.11477/mf.1403113949
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 FAP(familial adenomatous polyposis)and Lynch syndrome are both hereditary colorectal cancer conditions which are transmitted with autosomal dominant patterns However, the characteristics of phenotype are absolutely different among the two conditions. FAP is characterized by the presence of multiple adenomas distributed in the colon and rectum. The extracolonic manifestations are present, in particular gastric and duodenal polyps and desmoid tumours. The surgical resection and appropriate endoscopic surveillance had contributed to reduce the mortality. To survey the Lynch syndrome patient, microsatellite instability test is applied but it is not generalized enough in Japan. In both diseases, the report about the small intestinal neoplasia is still limited.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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