Issues on Histological Diagnosis of Depressed Gastric Lesion by Endoscopic Biopsy: Viewpoint of Clinical Course Hidenobu Watanabe 1 1The First Department of Pathology, Niigata University School of Medicine Keyword: 胃生検 , 組織診断基準 , Group分類 , 臨床経過 , 誤診 pp.941-948
Published Date 1990/8/25
DOI https://doi.org/10.11477/mf.1403111328
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 Issues on histological diagnosis of depressed gastric lesion by endoscopic biopsy are related to the two main areas; misdiagnosis by pathologist and histological criteria used.

 Pathologist's misdiagnosis can occur due to oversight, overdiagnosis or underdiagnosis. Causes of such a misdiagnosis were elucidated in this paper by comparing original diagnosis using endoscopic biopsy specimens with that using surgically obtained materials.

 Histological criteria used also pose some problems; (1) too much emphasis on histological atypia,(2) lack of distinctive or objective description of histological atypia,(3) lack of consideration about two types of atypia of cancer tissue, i.e., low-grade and high-grade atypias, and (4) a significant difference between histological criteria adopted by Japanese Group Classification and that by European and American Dysplasia Classification.

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