Assessment of Intestinal Absorptive Capacity for Sugar by Measurement of Breath Hydrogen and Transmural Potential Difference Makoto Ishikawa 1 , Tsuneo Takahashi 1 , Hisato Tada 1 , Masayuki Kaneko 1 , Hiroshi Masukawa 1 1The Second Department of Internal Medicine, Yamagata University, School of Medicine pp.789-795
Published Date 1985/7/25
DOI https://doi.org/10.11477/mf.1403109910
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 Firstly, breath hydrogen wasmeasured to delineate the absorptive capacity for sugars by our closed circulation system. There was a good correlation between the mean increase in breath hydrogen and D-xylose in urine five hour after loading of 25 g D-xylose. A mean increase of more than 1.9 ml/min in breath hydrogen was observed only in patients with short bowel syndrome. As an absorption test the hydrogen measurement after D-xylose loading may be more useful than the conventional D-xylose test since the breath test can be performed even for patients with malabsorption syndrome regardless of their age or renal function.

 By the H2 breath test unit (open system) the increased breath hydrogen after loading of 200 g dextrin was observed more frequently in aged subjects over the age of 70 than in any other age (p<0.01). Small intestinal transit time in aged subjects was not different from that in younger subjects, suggesting an impairment of absorptive capacity for sugar in the aged.

 Secondly, the absorptive capacity for sugar in patients with liver diseases was revealed by measurement of the transmural potential difference across the small intestine. Although D-glucose was absorbed normally in patients with liver diseases, the PDmax and Kt for the active electrogenic component of sucrose and maltose absorption in patients with liver cirrhosis seemed to be lower than those in the control group. This decrease may be derived from decreased activity of disaccharidases in the brush border in patients with liver cirrhosis.

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