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Changes in the Intestinal Microflora in Antibiotic Associated Colitis S. Hori 1 , M. Nakamura 1 , M. Yamamura 1 , T. Ohno 1 , T. Shimoyama 1 1The Forth Department of Internal Medicine, Hyogo College of Medicine pp.145-154
Published Date 1983/2/25
DOI https://doi.org/10.11477/mf.1403109273
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 Antibiotics tend to be used more often than before for various diseases and their use is more complicated and variegated than before. There is quite a lot of them now. At the same time, attention has been focussed on colitis in all probability caused by the administration of these antibiotics. Such a kind of colitis should always been borne in mind as one of the side effects of antibiotics whatever. It is more apt to occur in elderly individuals or when the original disease is serious. It is greatly related to the imbalance of intestinal microflora along with the lowered immune mechanism.

 Changes most often encountered are relative increase of fucultative anearobe and variegated species of enteric bacteria. Instead of E. coli, some other gram-negative rod-like bacilli at times become predominant as coliform bacilli. As for anaerobic bacilli, decrease in number of Bifidobacterium and Enterococci, and lactic bacteria was seen.

 Bacteroides (especially, B. fragilis), which usually alter little, decrease in number in pseudomembranous enteritis. Under such circumstances proliferated Cl. difficile, which is resistant to antibiotics, produces toxin.

 Therefore, sufficient administration of microbacterial preparation to prevent the above-mentioned alteration of the microflora is very important as is the effort to enhance the immunity of the patients according to their condition.


Copyright © 1983, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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