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Pedunculated Advanced Colonic Cancer with Multiple Systemic Metastasis, Report of an Autopsy Case Hideto Taniguchi 1 , Masaki Nakamura 1 , Naoto Kikuchi 1 , Akira Honma 1 , Kiyoshi Hoshino 1 , Kouichi Koizumi 1 , Masao Namiki 2 1Department of Internal Medicine, Yoyogi Hospital 2Department of Pathology, Yoyogi Hospital pp.1014-1018
Published Date 1988/9/25
DOI https://doi.org/10.11477/mf.1403108526
  • Abstract
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 A 72 year-old man with a two-year history of chronic respiratory failure was admitted with the chief com-plaint of dyspnea. Laboratory data on admission (Table 1) revealed hypoxia, hypercapnea, positive fecal occult blood, and elevation of LDH, ALP and CEA titer. About two weeks later he died of associated cardiac failure. At autopsy, a pedunculated polyp was noticed at the descending colon (Fig. 1, 2).

 Histological study, however, revealed well differentiated-poorly differentiated adenocarcinoma with extensive lymphatic and venous permeation from the submucosa to the serosa, as well as invasion of the stalk (Fig. 3~6). Moreovere, marked distant metastases including bilateral lung (Fig. 7), left adrenal gland, and multiple lymph nodes were noticed.

 It is very rare that the full thickness of the colonic wall is involved despite the fact that the lesion took the macroscopic form of a pedunculated lesion. This case is very interesting in considering the morphogenesis of large bowel cancer.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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