Growth Patterns of Protruded Lesions in the Dog Stomach Induced by N-methyl-N'-nitro-N-nitrosoguanidine M. Fujita 1 , T. Taguchi 1 , M. Takami 1 , M. Usugane 1 , A. Takahashi 1 , S. Shiba 1 1Department of Oncologic Surgery, Res. Inst. for Microb. Dis., Osaka Univ pp.661-669
Published Date 1973/5/25
DOI https://doi.org/10.11477/mf.1403108505
  • Abstract
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 The study of the developmental process of gastric cancer from the pathological and the clinical view points is an interesting subject.

 In 1970, we reported that multiple protruded lesions were produced with a high incidence limited to the anterior wall of the upper body of the dog stomach by N-methyl-N'-nitro-N-nitrosoguanidine (NG).

 In this paper is described the developmental progress of the lesions as determined by repeated roentgenographic and endoscopic examinations, and the histological features of the gastric lesions in two dogs followed up for 10 and 15 months respectively, after the tumor was first detected.

 The growth patterns of protruded lesions of dog stomach in NG carcinogenesis were of two types. Both types in early stages were found to be in the form of small plaques.

 Type A lesions were those that grew gradually both in height and width to assume a hemispherical shape and later developed into a polyp with a slight constriction at the base. Histologically, this type was either an atypical adenoma or a papillary adenocarcinoma.

 Type B lesions were those that developed to form broad-based polypoid lesions with a central depression, and later some of them developed into a form that resembled Borrmann type Ⅱ in shape. Microscopically, these tumors were either a leiomyosarcoma or a mixed tumor consisting of sarcomatous and atypical adenomatous elements.

 Type B lesions showed a more rapid rate of growth than type A lesions.

Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.


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