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Long-term Observation of Canine Stomach Cancer Induced by N-methyl-N'-nitro-N-nitrosoguanidine M. Takami 1 , M. Fujita 1 , A. Takahashi 1 , M. Usugane 1 , T. Taguchi 1 1Department of Oncologic Surgery, Research Institute for Microbial Diseases, Osaka Univ pp.1375-1386
Published Date 1977/10/25
DOI https://doi.org/10.11477/mf.1403112528
  • Abstract
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 Eighteen dogs were orally adiministered with 50 μg/ml of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 12 months, and followed up by endoscopy and biopsy. Five of them were monitored in detail, autopsied, and then given histological examinations.

 Almost all of the lesions were located on the anterior wall of the upper or mid-body of the stomach where severe erosive gastritis had occurred during administration of MNNG. We obtained 63 neoplasms in five dogs in which 34 lesions (56 per cent) were protruded. These protruded lesions appeared for the first time 10 months after the termination of MNNG administration. Some of them were found as type Ⅱb (flat) lesions with redness, and developed to type Ⅱa or Ⅰ (elevated) lesion.

 We observed the development and growth of the canine stomach cancers for from 32 months to 47 months and obtained new information about the growth of protruded lesions as follows :

 1. Biopsy examination proved that carcinomatous lesions occurred "de novo" and grew up to type Ⅰ early carcinoma through type Ⅱb and Ⅱa.

 2. The grade of atypism of the elevated lesions never changed from benign to malignant during biopsy study.

 3. The cancerous lesions, grew more rapidly than less atypical lesions.


Copyright © 1977, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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