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A Case of Oligoganglionic Megacolon Developed after Long-term Use of Creosotum Y. Ohta 1 , Y. Kato 1 , I. Kino 2 , T. Obara 3 , K. Hidai 3 1Dept. of Pathology, Faculty of Medicine, Univ. of Tokyo 2Dept. of Pathology, Hamamatsu Univ. School of Medicine 3The 2nd Dept. of Surgery, Faculty of Medicine, Univ. of Tokyo pp.1429-1433
Published Date 1978/10/25
DOI https://doi.org/10.11477/mf.1403107540
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 A 62-year-old man, who had taken Creosote pills orally for 30 years, was admitted with severe constipation and abdominal distention. His bowel habit during childhood was normal. Laparotomy revealed marked dilatation of the ascending and transverse colon. The colon distal to the splenic flexure appeared normal. There was no mechanical obstruction nor any other lesions. The level of resection was determined by multiple frozen sections of the bowel wall and the segmental resection was performed. The surgical specimen consisted of dilated and non-dilated segments in continuity, the latter of which was anal to dilated segment. Histological examination revealed remarkable degeneration and decrease in number of ganglion cells in the Auerbach's and Meissner's plexuses in the most proximal portion of the non-dilated segment, 50 cm in length and adjacent to the dilated segment. In the other distal portion of the non-dilated segment, however, the morphological appearance and number of the ganglion cells in both plexuses were within normal range. The nerve cells in Auerbach's plexuses of the dilated segment showed degeneration and decrease in number to a mild extent, that was interpreted as secondary change due to marked dilatation. Meissner's plexuses in the dilated segment were normal. From those observations and the history of this patient, it was concluced that segmental oligoganglionosis was caused by toxic damage due to long term intake of Creosote, which contains phenol, and aperistalsis in the oligoganglionic segment provoked megacolon secondarily. The reason why oligoganglionisis was localized in the portion of descending colon is discussed.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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