An Evaluation of the Treatment of Duodenal Ulcer over a Fourteen Year Period M. Nishizawa 1 , K. Nomoto 1 1Tokyo Metropolitan Cancer Detection Center pp.795-804
Published Date 1978/6/25
DOI https://doi.org/10.11477/mf.1403107347
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 By Studying duodenal ulcers found within a healthy population and observing patient response to treatment by oral medication given over a protracted period, we hoped to obtain statistical results for a complete recovery rate which would shed light on the efficacy of medication to prevent recidivation of duodenal ulcers.

 373 subjects, predominantly males aged 40-54, were chosen over a fourteen year period from among a healthy, working population of 4219 on the basis of having a past history of duodenal or gastro-duodenal ulcer including scarring. This obtains an incidence rate of 8.8%. Of the 373 subjects, 30 (8%) were operated on subsequent to beginning our study. However, by including those operated on prior to beginning our study and finding new cases of duodenal ulcer among the total population, incidence rate rises to 10.4% while operation rate changes to 21.5%.

 The number of subjects of total subject population observed in excess of five years totaled 154 ; of these, 30 subjects were considered to have demonstrated complete recovery. The remaining 124 subjects did not show complete recovery despite the administration of oral medication over a period of from five to fourteen years.

 Of these 124 cases, the number of subjects displaying scars which might indicate complete recovery at the time of admission to our survey was 38.7% ; by the end of our study, this number had risen to 66.9%. Dividing this into separate age groups produces the following results:

   Age   Beginning   End

  40~44   39.3%    71.4%

  45~49   41.4%    55.6%

  50~54   16.7%    68.8%

 Generally speaking, duodenal ulcers show a tendency to recidivation despite aggressive treatment. They most frequently occur between ages 20 to 40 and are considered to have a tendency to spontaneous healing with advancing age. Thus, the role played by medication in curing duodenal ulcers is somewhat obscured by the fact that many subjects may have healed spontaneously, and the results of this survey must be considered bearing this in mind.

Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.


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