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Whether Has Operative Indication for Peptic Ulcer Disease Been Changed by H2-Receptor Antagonist ? F. Nagao 1 , H Akimoto 1 , T. Aoki 1 1The Second Department of Surgery, The Jikei University School of Medicine pp.549-552
Published Date 1984/5/25
DOI https://doi.org/10.11477/mf.1403107031
  • Abstract
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 The operative indication for peptic ulcer disease has been divided into two categories. One is absolute indication as bleeding, stenosis and ulcer perforation, the other one is relative indication as intractable ulcer. The treatments for peptic ulcer are changing depending on the development of new medical therapy or based on new findings in gastric physiology. Since H2-receptor antagonist was introduced for the treatment of peptic ulcer, a significant decrease in surgical cases has been experienced within the recent couple of years. Gradual reduction of surgery for peptic ulcer disease has been seen for last three years. Especially relative indication was markedly dropped (Fig. 1). Otherwise, absolute indication including bleeding, stenosis and ulcer perforation shows different phenomenon. H2-receptor antagonist has some beneficial effects for bleeding cases (Table 1). But there are little effects upon the patient who has exposed arteries in ulcer base and/or who has other severe organ failure (Table 2). In conclusion, H2 receptor antagonist has some beneficial effects on-so called intractable or bleeding ulcer patients avoiding emergency surgery. However, it will be an important future problem to be solved, how long the patients with recurrent ulcer disease could be on H2-receptor antagonists therapy.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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