雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

The Indication and Efficacy of H2-Receptor Antagonist K. Saigenji 1 , Y. Yokoyama 1 , T. Mitsuhashi 1 , M. Ohida 1 , H. Okabe 1 1Department of Internal Medicine, Kitasato University, School of Medicine pp.499-506
Published Date 1984/5/25
DOI https://doi.org/10.11477/mf.1403107021
  • Abstract
  • Look Inside

 1. Review of the efficacy of H2-receptor antagonist. The efficacy of H2-receptor antagonist (H2-blocker) for peptic ulcer was reported in many articles. In the placebo-controlled studies, all cimetidine regimens were associated with a statistically significant increase in the frequency of ulcer healing. Reports of multi-clinic double blind studies with three H2-blockers (cimetidine 800 mg, ranitidine 300 mg, famotidine 40 mg daily) in Japan were equally more effective for peptic ulcer healing than gefarnate.

 2. Open trials with H2-receptor antagonist and other anti-ulcer drugs for peptic ulcer patients in Kitasato University Hospital. Fifty-five outpatients with duodenal ulcer were treated with H2-blocker or con-ventional medical treatment. Endoscopy was performed at intervals of three and six weeks. Healing rates at three and six weeks were 41.7% (15/36), 82.9% (29/35) with H2-blocker and 23.5% (4/17), 55.5% (10/18) with conventional treatment. 131 cases gastric ulcer patients were treated with H2-blocker, antacid, so called mucosal protector, conventional regimen and H2-blocker with other anti-ulcer drugs. Healing rates at two, four, six and eight weeks with various drugs were compared retrospectively. Healing rates with H2-blocker were as follows: 49.7% (22/54) at four weeks, 69.2% (27/39) at six weeks, 79.5% (35/ 44) at eight weeks respectively. The efficacy of H2-blocker was superior to any other drugs at four and six weeks.

 3. Indication of H2-receptor antagonist for peptic ulcer. H2-blocker treatment is necessary in the treatment of all duodenal ulcers, all combined ulcers, and gastric ulcers located in the angle and pyloric antrum.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有