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Histamine H2-Receptor Antagonist and Recurrence of Peptic Ulcer K. Iwakoshi 1 , H. Oka 1 , K. Abe 1 , S. Asada 1 , S. Ohshiba 1 1The Second Department of Internal Medicine, Osaka Medical College pp.515-520
Published Date 1984/5/25
DOI https://doi.org/10.11477/mf.1403107023
  • Abstract
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 In this report, we studied the recurrence of peptic ulcers which were treated with H2-receptor antagonist (ranitidine). Subjects we studied were 67 gastric ulcers and 56 duodenal ulcers. The most important factor in preventing recurrence was treatment with drugs. Especially, continuous treatment with ranitidine prevented the recurrence of ulcers significantly.

 In the study of the cumulative recurrence rate, we obtained the following results: 1) The recurrence rate of the treated group was significantly lower than the untreated group but there was no difference among the variety of drugs we studied. 2) The difference of recurrence rate between both groups became smaller after 12 months since the ulcers had healed.

 Therefore, in those cases of peptic ulcer treated with ranitidine, we speculate that treatment with drugs prevented the recurrence of ulcers caused by acid rebound during the early stage (within one year after healing).


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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