Pathological Aspects of Hepatolithiasis Y. Nakanuma 1 , T. Terada 1 , G. Ohta 1 1The Second Department of Pathology, School of Medicine, Kanazawa University pp.405-411
Published Date 1984/4/25
DOI https://doi.org/10.11477/mf.1403107000
  • Abstract
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 In hepatolithiasis stone-containing bile ducts revealed dilatation and relative stenosis, and histologically disclosed “chronic proliferative cholangitis”. The latter was characterized by fibrosis, inflammatory cell infiltration and proliferation of glandular elements. These three elements were different from case to case or at several levels of the biliary tree. Secreted mucin from these proliferated glandular elements might do much in the genesis of hepatolithiasis. Some cases might have been preceded by intrahepatic bile duct dilatation, especially solitary intrahepatic bile duct dilatation. Intrahepatic cholangiocarcinoma might complicate some cases of hepatolithiasis (<10%), and hyperplastic atypical biliary epithelia in chronic proliferative cholangitis might be a precursor lesion of carcinoma.

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