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A Pathogenesis of Chronic Duodenitis Kenzo Kobayashi 1 , Kayoko Kawada 1 , Hiroko Nebiki 1 , Teisuke Kamata 1 1The Third Department of Internal Medicine, Osaka City University Medical School pp.1221-1229
Published Date 1989/11/25
DOI https://doi.org/10.11477/mf.1403106608
  • Abstract
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 Chronic duodenitis (primary) is a condition of unknown cause characterized by inflammation involving the mucosa of the duodenum (especially first part) with no signs of past or present ulceration.

 This condition has been recognized for more than 2 centuries.

 The early literature on this condition was based on findings obtained at surgery and later by radiology. The major advances in our understanding of this disease started with the introduction of peroral duodenal biopsy. Subsequently, the introduction of fiberoptic endoscopy allowed direct visualization of the duodenum, and target biopsies of suspicious areas of mucosa can be easily obtained.

 The clinical importance of duodenitis in the absence of chronic ulceration remains controversial.

 Ostrow and Resnick (1959) developed a hypothesis which proposed a pathological sequence of hyperchlorhydria, duodenitis and duodenal ulcer as steps in the peptic ulcer diathesis. On the contrary, Cheli observed that the majority of patients with duodenitis had hypochlorhydria or achlorhydria. Therefore, this study does not support the theory of “peptic duodenits”.

 Prospective studies should be required including long-term clinical follow-up of a large number of patients with duodenitis, accurately and specifically diagnosed by endoscopy and histopathology.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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