Japanese

Gastrointestinal Carcinoid Tumors of Japanese: Incidence and Characteristics Based on Anatomical Classification, with Special Reference to Difference between Carcinoid Tumor and Endocrine Cell Carcinoma Mitsuya Iwafuchi 1 , Hidenobu Watanabe 1 , Yutaka Noda 1 1The First Department of Pathology, Niigata University School of Medicine pp.869-882
Published Date 1989/8/25
DOI https://doi.org/10.11477/mf.1403106529
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 220 carcinoid tumors (CD) of 194 cases and 8 endocrine cell carcinomas (ECC) of Japanese patients were examined.

 In Japanese population, the rectum is the most favorable site of occurrence of CD and the incidence of CD of each site was as follows; stomach: 13%, duodenal 1st portion: 21%, duodenal 2nd portion: 7%, jejunum: 1%, ileum: 2%, appendix: 11% and rectum: 45%.

 According to the anatomical classification, CD of duodenal 1st portion are characterized by gastrin-family cells immunohistochemically and intestinal G cell ultrastructurally, CD of duodenal 2nd portion by somatostatin cells and D cells, CD of appendix by peptide YY cells and D1 and/or L cells, and CD of rectum and colon by PP, PYY and glicentin cells and D1 and/or L cells. Gastric argyrophil CD were characterized by ECL, D1 and/or X cells but their hormonal substance remain unclear. Argentaffin CD consisted mainly of serotonin cells and ECn and/or EC1 cells unrelated to occurring sites.

 Gastrointestinal endcrine cell tumors should be devided into CD, low-grade malignancy, and ECC, highgrade malignancy.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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