Pathogenesis of Acute Gastric Mucosal Lesion Hideto Tsukamoto 1 , Yoshiki Hiki 1 , Hiroyoshi Mieno 1 , Katsunori Saigenji 2 1Department of Surgery, Kitasato University School of Medicine 2Department of Internal Medicine, Kitasato University School of Medicine pp.645-651
Published Date 1989/6/25
DOI https://doi.org/10.11477/mf.1403106477
  • Abstract
  • Look Inside

 From July 1971 to December 1987, 231 cases of acute gastric mucosal lesions (AGML) diagnosed definitively by endoscopy were examined at Kitasato University Hospital. The main inducing factors of AGML were drugs (87 cases), emotional stress (57 cases) and unknown (51 cases). Physical stress causing AGML included surgical operation in nine patients, burn in three and trauma in two. On pathogenesis of AGML, there are many reports indicating defensive factors (mucosal blood flow, mucus production, etc) play more important role than aggressive factors (gastric acid and pepsin secretion). However, with respect to surgery-related stress ulcer caused by vagal stimulation, sympathetic stimulation and adrenocortical hypersecretion, it is considered essential that the balance between aggressive factors and defensive factors is disturbed.

Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院