大腸腺腫と大腸癌―特に腺腫の経過観察について

Clinical Course of Colonic Adenoma

要旨　大腸腺腫281病変について，1年～6年11か月の経過観察および，ポリペクトミーまたは手術の施行された腺腫76病変，m癌107病変，sm癌25病変の分析と経過観察から次のような結果を得た．（1）腺腫の経過観察から癌化および大きさの増大はみられなかった．（2）平板状隆起は，sm癌，m癌の順に多く，腺腫の大多数はポリープ状を示した．（3）m癌の2～3年の経過観察では，大きさ，形態の変化はみられなかった．（4）生検診断と標本組織診断の間には，かなりのdiscrepancyがみられ，生検診断は過小に診断する傾向がある．

　Study was conducted on colonic adenoma using our data: 281 lesions of colonic adenoma periodically observed for 1 year to 6 years 11 months, 76 lesions of adenoma either polypectomized or surgically removed, 107 lesions of m cancer and 25 lesions of sm cancer.

　The results are as follows.

　1. Periodic observations showed that colonic adenoma neither transformed into malignancy nor increased in size.

　2. Most of the sessile elevations were sm cancer followed by m cancer in frequency, while a great majority of adenomas were polypoid in shape.

　3. Clinical observations for 2 to 3 years showed that m cancer did not change in size or shape.

　4. There was a significant discrepancy between biopsy findings and histological diagnoses using resected specimen. Biopsy findings tended to be underdiagnostic of malignancy.