Prospective and Retrospective Study on Natural Progression of Esophageal Cancer Mamoru Nishizawa 1 1Tokyo Metropolitan Cancer Detection Center pp.1229-1237
Published Date 1988/11/25
DOI https://doi.org/10.11477/mf.1403108744
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 Eleven cases of esophageal cancer were analysed prospectively and retrospectively. In nine of these cases, cancer was confirmed retrospectively either by patient death during follow-up treatment on during surgical operation. In the other two cases there had been follow-up for periods of 5 years 5 months, and 2 years 6 months respectively. The follow-up began prospec-tively as soon as a diagnosis of squamous-cell cancer was made at the initial biopsy.

 Based on an analysis of these 11 cases, the following deductions were made concerning the natural progression of esophageal cancer.

 (1) Progression of mucosal cancer discerned by endoscopy is slow, presumably a few years.

 (2) Progression of esophageal cancer of which depth invasion reaches sm and deeper is rapid. Once sm cacer is suspected, the earliest possible steps including surgical operation and other treatments should be taken.

 (3) Esophageal cancers detected by x-ray were more likely to show rapid growth, but actually, this is not the case with esophageal cancer previous to detection by x-ray. It is a mistake to define the progression of mucosal cancer in terms of follow-up after x-ray.

 (4) Generally defferential diagnosis of mucosal (especially ep) cancer, dysplasia, and esophagitis is difficult. This fact should be taken into account in estimating the natural progression rate by basing analysis on esophageal cancers diagnosed by biopsy and followed-up.

Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.


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