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Japanese

Morphological Conditions of Familial Adenomatous Polyposis Clarified by Clinical Study Kyosuke Ushio 1 1Department of Diagnostic Radiology, National Cancer Center Central Hospital Keyword: 家族性大腸腺腫症 , Gardner症候群 , APC遺伝子 , 大腸癌 , 骨腫 pp.1305-1321
Published Date 1993/11/25
DOI https://doi.org/10.11477/mf.1403106312
  • Abstract
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 Familial adenomatous polyposis (FAP) is characterized as follows; 1) it is inherited in an autosomal dominance, 2) usually several hundreds or more than thousands adenomatous polyps carpet the colon and rectum, 3) almost all patients with FAP develop carcinoma of the colon if the colon has not been removed, 4) the causative gene being located on the long arm of the fifth chromosome (5p21-22) was isolated in 1991 and was named the APC gene. We describe the history of its research, especially focus on the Japanese studies on the lesions in the upper gastrointestinal tract and mandible, and the difference between FAP and Gardner's syndrome. Then, recent advances in clinical study which have disclosed the nature and pathophysiology of this disease are reported. Furthemore, from the clinical points of view, we mention the subject of its genetic study which is expected to make rapid progress in the future.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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