Desmoid Tumors:From the Viewpoint of Long-term Follow-up Shozo Baba 1 , Toshiyuki Kozato 2 1Department of Surgery Ⅱ, Hamamatsu University School of Medicine 2Department of Surgery, Shizuoka Prefectural General Hospital Keyword: 家族性大腸腺腫症 , APC遺伝子 , 腹腔内デスモイド , 腹壁デスモイド pp.577-584
Published Date 1997/3/25
DOI https://doi.org/10.11477/mf.1403105101
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 The desmoid tumor is a benign growth of fibroaponemtic tissue which is rare as a sporadic disease, however, it develops in about 10% of the patients with familial adenomatous polyposis (FAP). Both intraabdominal and abdominal wall desmoids may develop as FAP related desmoid tumors. Desmoid tumors are common in young female patients of productive age. Occasionally desmoids seem to cluster in FAP families. If a patient with a “desmoid family”, colectomy should be deferred as long as possible. The cloning of APC gene enables presymptomatic diagnosis in clinical practice and preventive surgery in the future. Therefore, the development of new treatment for desmoid tumor will be neccessary. Presently, tamoxifen and sulindac treatment is recommended for desmoid, however responce rate is approximately 60%. Efficacy of doxorubicin (adriamycin) has been recently reported. Desmoid usually develops within three years after operation. It might be advisable to treat patients of desmoid family prophylactically with tamoxien and sulindac for the post operative period.

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