Cronkhite-Canada症候群の消化管ポリープの経過―最近10年間の本邦経過観察例の文献的考察を含めて

Course of Gastrointestinal Polyps of Cronkhite-Canada Syndrome: Including Review of 53 Cases Reported in Japanese Literature During the Last Ten Years

要旨　Cronkhite-Canada症候群の自験例6例と1983～1992年の10年間の本邦文献例53例における消化管ポリープ（CCポリープ）の経過について検討した．CCポリープの大部分は1年前後で縮小したが，消失までに至った例は約1/3であった．消失までの平均月数は胃・大腸ともほぼ等しく30か月であった．本症候群における腺腫合併例の頻度は自験例では6例中4例に認め，文献例では胃腺腫5.7％，大腸腺腫18.9％であった．長期経過例中の残存ポリープにおける腺腫の割合は高いものと推定されたが，CCポリープが年余にわたりみられる例もあり，今後は，ポリープのnatural historyという視点に立った一層の経過観察が必要であろう．

　We analyzed long-term observation of Cronkhite-Canada polyps (CC polyps) in our six cases and in 53 cases reported in Japanese literature during the last ten years from 1983 to 1992.

　Most CC polyps diminished for about one year. Complete disappearance was observed in one third of CC patients. Duration until disappearance of CC polyps is 30 months on average in both the stomach and large intestine.

　Association with gastrointestinal adenoma was found in four out of six of our patients. In the reviewed cases this association was found in the stomach in 5.7% of the cases and in the large intestine in 18.9% of the cases.

　Prevalence of adenoma in long-term patients is presumably higher. Further research from the standpoint of the natural history of CC polyps is expected.