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Pathological Feature of Primary Gastric Lymphoma Nobutaka Ono 1 , Haruki Wakasa 1 1Department of Pathology, Fukushima Medical College Keyword: 悪性リンパ腫 , MALTリンパ腫 pp.1007-1012
Published Date 1993/9/25
DOI https://doi.org/10.11477/mf.1403106254
  • Abstract
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 Most primary gastric lymphomas are B-cell lymphomas. According to the LSG classification, more than 90% of all malignant lymphomas of the stomach are diffuse lymphoma (DL). Diffuse large-cell type lymphoma (DL-large) is the most commonly observed case in the stomach as well as among nodal lymphomas, and the medium-sized-cell type (DL-medium) is also frequently found. Using immunohistochemical study, the histogenesis of gastric lymphoma is classified as being of prefollicle, follicle and postfollicle center cell origin. Follicular lymphomas and the majority of DL-large are positive for CD 10, suggesting follicle center cell origin. DL-medium, positive for sⅠgD, CD 5 or ALPase, is encounterd as being prefollicle center cell, corresponding to mantle zone lymphocytes. DL-small (lymphoplasmacytoid) and DL-large (immunoblastic type) with monoclonal cytoplasmic immunoglobulin usually originate from postfollicle center cell outside of the follicle. MALT lymphoma proposed by Isaacson is characterized by extranodal-site occurrence. These were mainly observed in the gastrointestinal tract, thyroid gland, bronchus, salivary gland and thymus, etc. MALT lymphoma is considered to arise from the marginal zone of the follicle, which we call the outer layer of the mantle zone.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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