Malignant Lymphoma of the Rectum : A Clinicopathological Analysis of 23 Patients Shotaro Nakamura 1 , Shunichi Yanai 1 , Kouhei Fujita 2 , Minako Hirahashi 2 , Shigeo Nakamura 3 , Ritsuko Yanaru-Fujisawa 1 , Takayuki Matsumoto 1 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Division of Gastroenterology, Nippon Steel Yawata Memorial Hospital, Kitakyushu, Japan Keyword: 直腸悪性リンパ腫 , MALTリンパ腫 , DLBCL , 濾胞性リンパ腫 , T細胞性リンパ腫 pp.1359-1370
Published Date 2010/7/25
DOI https://doi.org/10.11477/mf.1403101990
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 The clinicopathological features of 23 patients with malignant lymphoma of the rectum were retrospectively analyzed. Histologically, 9 cases were classified as MALT lymphoma, 3 as follicular lymphoma, 1 as mantle cell lymphoma, 4 as diffuse large B-cell lymphoma, and 6 as T-cell lymphoma. Six of 8 cases(75%)of polypoid form on macroscopy were MALT lymphomas, while 6 of 9 cases(67%)of diffuse or mixed forms were T-cell lymphomas. In addition, 3 of 4 cases(75%)of lymphomatous polyposis type were follicular lymphomas. The overall survival(OS)and the event-free survival(EFS)did not differ between patients who were treated non-surgically(watchful waiting, antibiotics, chemotherapy or radiotherapy ; n=15)and those treated by surgery(n=8). Cox multivariate analysis revealed that indolent histology(MALT lymphoma or follicular lymphoma)was an independent prognostic factor for both OS and EFS. Intestinal perforation, B symptoms, B/T phenotype and clinical stage were also independent prognostic factors for EFS, but not for OS.

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