Characteristics of Colorectal Cancer with False-Negative Fecal Occult Blood in Screening Health Care Examination Nobuo Hiwatashi 1 , Tomizo Morimoto 2 , Nobuyuki Sugawara 2 , Hirofusa Sato 2 , Takayoshi Toyota 1 1The Third Department of Internal Medicine, Tohoku University School of Medicine 2Cancer Detection Center of Miyagi Cancer Society Keyword: 大腸がん集検 , 偽陰性例 , 偽陰性率 , 免疫学的便潜血検査 , 逐年検診 pp.833-838
Published Date 1993/7/25
DOI https://doi.org/10.11477/mf.1403106221
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 We have performed screening examinations for colorectal cancer since 1983 using several fecal occult blood tests and questionnaire. For evaluating the characteristics of patients with false-negative fecal occult blood and the false-negative rate, we analyzed the results of 2-day immunochemical tests.

 In our study, 'false-negative' case was defined as a person who was diagnosed or judged to have colorectal cancer within 1 year since a negative fecal occult blood test. These cases were collected by the investigative reports, screening examination or questionnaire of the next year.

 Most of false-negative cases were diagnosed by the screening examination of the next year and two thirds of them were early cancers. All cases picked up by the questionnaire were early cancers. On the other hand, all reported cases were advanced cancers. False-negative cases were likely to be early diseases and/or less than 30 mm in diameter. As for the location, rectal and rightsided colon cancers were common in false-negative cases. The false-negative rate was 41.2% in all cases. If early or Dukes A cancers were excluded from the false-negative cases, the false-negative rates were 14.1% or 8.4%, respectively. These rates may be acceptable to the public and not inferior to the false-negative rate of indirect roentgenography in gastric cancer mass screening.

Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.


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