Intractable Gastric Ulcer and Complications Kazumichi Harada 1 , Hisato Hara 1 , Akira Uehara 1 , Masayoshi Namiki 1 1The Third Department of Internal Medicine, Asahikawa Medical College Keyword: 難治性潰瘍 , 慢性関節リウマチ(RA) , NSAIDs pp.293-298
Published Date 1993/3/25
DOI https://doi.org/10.11477/mf.1403106116
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 Intractable gastric ulcer has been defined as the ulcer which is not healed (scarred) over 3 months after the initiation of anti-ulcer treatment. The recenta dvent of H2 blockers or proton pump inhibitors (PPIs) has increased the 8-week healing rate up to as high as 90%. We therefore defined here intractable gastric ulcer as the one which failed to reach the healing stage within 8 weeks in spite of adequate therapy using H2 blockers or PPIs. The incidence of intractable gastric ulcer was 42 (11.8%) of the 357 ulcer patients examined. Intractable gastric ulcer was more frequently observed in recurrent ulcer patients, and its common complications ineluded rheumatoid arthritis, liver disease and diabetes mellitus. Many patients with intractable gastric ulcer had long taken steroid hormones or nonsteroidal antiinflammatory drugs for their complications, while nearly the half of intractable ulcer patients had no history of drug-taking or complication, thereby suggesting that the pathogenesis of intractable gastric ulcer was not uniform but multiform.

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