Submucosal Invasive Endocrine Cell Carcinoma of the Rectum with Metastasis to the Brain, Skin and Mediastinum, Report of a Case Takeyasu Suda 1 , Katsuyoshi Hatakeyama 1 , Yasuo Sakai 1 , Haruhiko Okamoto 1 , Hidenobu Watanabe 2 1The First Department of Surgery Niigata University School of Medicine 2The First Department of Pathology, Niigata University School of Medicine Keyword: 内分泌細胞癌 , 直腸sm癌 , p53遺伝子変異 , Ki-67標識率 pp.1302-1306
Published Date 1994/11/25
DOI https://doi.org/10.11477/mf.1403105973
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 A 63-year-old man was admitted to our hospital with complaints of bloody stool and anal prolapse. Colonofiberscopic examination revealed a subpedunculated tumor in the lower rectum which was removed endoscopically. Histologically, the removed tumor showed an endocrine cell carcinoma with massive submucosal invasion, the cut margin of which was suspected of having been invaded by the cancer. A colonic J shaped pouch-anal anastomosis following low anterior resection with dissection of D3 lymph nodes was carried out. Histologically, the resected specimen showed no residual cancer in the rectum, but there were cancer metastases to several regional lymph nodes. Two years and two months after the operation, the patient died of metastatic endocrine cell carcinoma to the brain, skin and mediastinum. A clinical case of endocrine cell carcinoma with poor prognosis was reported. In addition, immunohistochemical and molecular biological characteristics of the tumor are discussed in this paper.

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