Familial Adenomatous Polyposis Associated with Carcinoma of the Thyroid Gland, Report of a Case Keigo Yoshinaga 1 , Takeo Iwama 1 , Jun Kanno 2 , Atsushi Inoue 1 , Yoshio Mishima 1 1The Second Department of Surgery, Faculty of Medicine, Tokyo Medical and Dental University 2Department of Pathology and Immunology, Faculty of Medicine, Tokyo Medical and Dental University Keyword: 家族性大腸腺腫症 , 頸部腫瘤 , 甲状腺癌 pp.647-651
Published Date 1997/3/25
DOI https://doi.org/10.11477/mf.1403105112
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 We report a 21-year-old woman with familial adenomatous polyposis (FAP) associated with carcinoma of the thyroid gland. She had no family history of FAP. Palpation and ultrasonography examination of the neck revealed three well-defined masses in the thyroid. Colonoscopy showed sparse-type polyposis in the colon and rectum. She underwent subtotal thyroidectomy with modified neck dissection and total colectomy with ileo-rectal anastomosis. Histologic examination revealed three papillary carcinomas in the thyroid gland and early carcinomas in 13 colonic polyps of which the diameters were larger than 10 mm. A review of the Japanese literature reveals the following characteristics of thyroid carcinoma in FAP patients; female predominance, early onset in youth, papillary carcinoma with multicentricity and association of colon cancer. Regular examination of the thyroid gland including palpation and ultrasound examination should be part of the routine follow-up of female FAP patients from the age of puberty.

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