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Local Resection of the Duodenal Papillary Lesion of Familial Adenomatous Polyposis Takeo Iwama 1,2 , Hiroshi Tomita 2 , Masahiro Toyooka 2 , Keigo Yoshinaga 2 , Shinichiro Kume 3 1Human Gene Sciences Center, Tokyo Medical and Dental University 2The Second Department of Surgery, Tokyo Medical and Dental University 3Department of Surgery, Toshiba Hospital Keyword: 家族性大腸腺腫症 , 十二指腸乳頭部癌 , 十二指腸乳頭局所切除術 pp.593-600
Published Date 1997/3/25
DOI https://doi.org/10.11477/mf.1403105103
  • Abstract
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 The relative risk of peri-ampullary carcinoma is high in patients with familial adenomatous polyposis (FAP). We evaluated the effectivity of local treatment of the ampullary lesion of FAP patients. By August 1996, 52 FAP patients underwent duodenal endoscopic examinations. We classified the change of ampullary lesions as follows: normal, the superficial type, the protruding type and overt cancer.

 Among them, 14 cases were treated for the ampullary lesions: Five cases underwent pancreato-duodenectomy (PD) and nine cases were treated by local excision (LE) of the ampulla. All PD cases were preoperatively diagnosed as the protruding type or overt cancer. Except for two cases who were operated for both colon and ampullary lesions simultaneously, the average time span between colorectal surgery and treatment of ampullary lesion was 11.3 years. Two out of five PD cases had neither invasion into duodenal wall and pancreas nor lymph node metastases. In nine LE cases, two cases were complicated with temporal bile leak, and one of which underwent choledocho-duodenostomy due to stenosis. One case developed desmoid tumor. Three LE cases was diagnosed as carcinoma; two of their endoscopic diagnosis were the protruding type and the other one was the superficial type. Blood chemistry results of these three cancer cases were within normal limits, and their cholangiographic examinations were also normal. One of LE case died of recurrence of rectal cancer. The other eight cases had no recurrence on the ampullary lesion during the follow-up period from two years and four months to five years and two months. Local excision in an appropriate indication for ampullary tumor of the protruding type without evidence of invasion to the pancreas or duodenal wall in the FAP patients.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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