Minute Invasive Squamous Cell Carcinoma of the Esophagus Associated with Head and Neck Cancer, Report of Two Cases Manabu Muto 1 , Atsushi Ohtsu 1 , Narikazu Boku 1 , Takahiro Hasebe 2 , Atsushi Ochiai 2 1Department of Gastrointestinal Oncology and Gastroenterology, National Cancer Center Hospital East 2Division of Pathology, National Cancer Center Research Institute East Keyword: 食道扁平上皮癌 , 微小浸潤癌 , 発育進展 , 多発ヨード不染帯 pp.591-596
Published Date 2000/3/25
DOI https://doi.org/10.11477/mf.1403104678
  • Abstract
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 We reported two cases of minute invasive squamous cell carcinoma of the esophagus (ESCC) associated withhypolaryngeal cancer, in which sizes of ESCC were 5 mm and 4 mm, respectively. In both cases, invasion of cancer cells vertically into the submucosa was remarkable compared to the horizontal spread. This finding suggests that some ESCCs can invade vertically with-out horizontal spread in their infancy.

 In the cases of head and neck cancer and ESCC, we frequently observed multiple lesions in the esophagus unstained by iodine. The cases presented here also had such lesions. However, it is impossible to examine all of the lesions histologically and it has not been clear how we should manage these lesions. Our cases might provide an important implication for the management of multiple lesions in the esophagus unstained by iodine including minute lesions less than 5 mm in diameter.

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