Immunohistochemical Study of the Proliferative Activity and Angiogenesis of Superficial Esophageal Carcinoma Osamu Chino 1 , Hiroyasu Makuuchi 1 , Kyoichi Mizutani 1 , Hideo Shimada 1 , Takayuki Nishi 1 1Department of Surgery, School of Medicine, Tokai University Keyword: 食道表在型扁平上皮癌 , 腫瘍細胞増殖能 , 血管新生 , モノクローナル抗体 , MIB-1 , 第VIII因子関連抗原 pp.563-571
Published Date 2000/3/25
DOI https://doi.org/10.11477/mf.1403104673
  • Abstract
  • Look Inside
  • Cited by

 The correlation of clinicopathologcal characteristics with proliferative activity and angiogenesis was investigated immunohistochemically to assess the growth of superficial esophageal carcinoma. The cases of squamous cell carcinoma in the thoracic esophagus which underwent surgical resecion without preoperative treatment were studied. The labeling index (LI) to evaluate the proliferative activity of MIB-1 was calculated as the number of positive nuclei per 1,000 cancer cells counted. Factor VIII-related antigen was used to measure the mean number of blood vessels and blood-vessel surface area (%) inside the tumor (intratumor) and in the normal tissue around the tumor (extratumor) . The LI of MIB-1 of depth m3 carcinoma was significantly higher than that of m1or m2 carcinoma. The LI of poorly differentiated carcinoma was significantly higher than that of well or moderately differentiated carcinoma. The LI of cases of lymph node metastasis or lymphatic invasion was significantly higher than in cases without it. The mean intratumor blood-vessel surface area (%) was significantly smaller in m1 or m2 lesions than in lesions with greater depths. These results suggested that the growth of esophageal carcinoma may accelerate after the invasion of the muscularis mucosa (depth m3) with the increase of proliferative activity. Intratumor angiogenesis may contribute to the process by which superficial esophageal carcinoma grows from m1/m2 to m3.

Copyright © 2000, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院