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Japanese

Follow-up Study of Esophageal Dysplasia: It's Diagnosis and Histological Change Shingo Ishiguro 1 , Tsutomu Kasugai 1 , Yoshihiko Hoshida 1 1Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases Keyword: 食道dysplasia , 経過観察 , 病理診断 , p53 , Ki-67 pp.695-704
Published Date 1996/5/25
DOI https://doi.org/10.11477/mf.1403104151
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 To know the true nature of esophageal dysplasia, we examined 44 follow-up cases of esophageal dysplasia.

 In biopsy of borderline lesions, there was disagreement among specialists about histological diagnosis. For example, the histological diagnosis recieved from the institution where the case was presented might differ from that of the specialist in digestive pathology.

 Immunohistochemical staining of tumor suppresser gene p53 product and Ki-67 were helpful indicators for making diagnosis more accurately. They were useful for histological diagnosis of cancer, and in particular, were useful in diagnosis of borderline lesions.

 In the follow-up period during this examination, only one of 25 lesions was regarded as a borderline lesion was changing into cancer.

 On the other hand, many lesions diagnosed as histologically non-tumor were showed weak p53 positivity by immunohistochemistry. Accordingly, from a genetic point of view, the possibility of the existence of premalignant lesion (dysplasia) was suggested.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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