Histological Analysis of the Serrated Glands and Differential Diagnosis of the Hyperplastic Polyp and Serrated Adenoma Shin-ichi Nakamura 1 , Hajime Sato 1 , Tamotsu Sugai 1 1Division of Pathology, Central Clinical Laboratory, School of Medicine, Iwate Medical University Keyword: 過形成ポリープ , 鋸歯状腺腫 , 細胞更新 , carcinoembryonic antigen , AgNOR pp.843-849
Published Date 1998/5/25
DOI https://doi.org/10.11477/mf.1403103722
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 Serrated glands found in hyperplastic polyps (HP) and serrated adenomas (SA) showed characteristic morphological features consisting of tall columnar cells with intraluminal papillary projection and short columnar cells with a concave portion. The luminal contour of these columnar cells depicted the serrated lumen. These columnar cells were similar to those found in the upper part of normal colonic mucosa where successive morphological changes occur in the epithelium from crypt openings to the surface as a terminal process of cell renewal. The tall columnar cells in serrated glands seemed to correspond to the surface epithelium of normal mucosa and short columnar cells correspond to epithelium lining the crypt openings. Immunohistochemical staining using carcinoembryonic antigen and Ki-67, supported the homologous features found in serrated glands and in the superficial part of normal mucosa. Difference between SA and HP was considered to be due to whether the proliferating cells participate in the serrated glands or not. Mitotic figures or Ki-67 positive nuclei were confined to the lower portion of the HP and they were seldom observed in serrated glands. On the other hand, mitotic figures or Ki-67 positive nuclei were scattered throughout the whole area of SA including serrated glands. We calculated the Ki-67 positive rate (Ki-67 PR) and the number of intranuclear dots of argyrophilic nucleolar organizer regions (AgNOR number) in 26 lesions of typical HP and in 38 lesions of typical SA to verify our criteria for differentiation between HP and SA. Significant differences were obtained in both the Ki-67 PR and the AgNOR number of both groups.

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