Histological Differences between Cap Polyposis and Polypoid-type MPS of the Large Intestine Hideki Hashidate 1 , Hidenobu Watanabe 1 , Yoichi Ajioka 1 1The First Department of Pathology, Niigata University School of Medicine Keyword: cap polyposis , mucosal prolapse , 線維筋症 , スルフォムチン , シアロムチン pp.661-670
Published Date 2002/4/25
DOI https://doi.org/10.11477/mf.1403103510
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 The aim of this study is to clarify the histological differences between cap polyposis (CP) and mucosal prolapse (MP). We analyzed 22 CP lesions from 12 patients and 36 polypoid-type MP lesions from 36 cases, using H・E and (immuno) histochemical staining of MUC1,MUC2,MUC5AC,HID-AB,MSA, Desmin, Ki-67, and p21/WAF1.

 CP showed three significant differences in histology from MP; (1) infrequenct cryptal branching in the lower part of the crypts (CP: polypoid-type MPS=18.2: 86.1%, p<0.001), (2) lots of sialomucin (70: 0%, p<0.001) and (3) infrequent desmin-positive cells in the upper part of the lamina propria (12.5%: 100%, p<0.001). The distribution of Ki-67 positive cells was regular in CP, and it was one of the reason inducing infrequenct cryptal branching. We concluded that CP could be histologically distinguished from polypoid-type MP by referring to the above findings.

 On the other hand, there were no differences in expression of mucin core protein, existence of superficial erosion, granulation tissue, fibrinopurulent exudate and other findings between CP and polypoid-type MPS. The differences mentioned above was only at the degree of histological findings, and not essential. These results suggest that CP and MP may have the same pathogenesis; focal mucosal prolapse at least in the incipient stage of development.

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