Mucosal Prolapse Syndrome and Cap Polyposis Shinsuke Funakoshi 1 , Yasushi Iwao 2 , Hiroyuki Imaeda 2 , Toshifumi Hibi 1 , Kaori Kameyama 3 , Makio Mukai 3 1Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 2Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo 3Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo Keyword: 粘膜脱症候群 , cap polyposis , 線維筋症 pp.1331-1338
Published Date 2010/7/25
DOI https://doi.org/10.11477/mf.1403101987
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 This paper shows the clinical and morphologic characteristics of the MPS(mucosal prolapse syndrome)and CP(cap polyposis). Chronic mechanical stimulation by abnormal colonic motility and mucosal ischemia are likely to have occurred at defecation in MPS leading to thickening and fibrosis of the colorectal wall, as well as colonic diverticula and the adjacent mucosa to artificial stoma. There are three types of MPS, protruded-, ulcerative- and flat-type in the classification. In the ulcerative type, the lesion is frequently distant from the anal verge, whereas it is adjacent to it in the protruded type. On the other hand, CP is a rare disorder, which has developed multiple broad-based elevated polypoid lesions on the apices of the semicircular fold in the rectum and sigmoid colon. However, the pathogenesis of CP remains uncertain. The symptoms such as mucous bloody stool and mucous diarrhea were noted more in CP than in MPS. In addition, CP, but not MPS, is associated with hypoproteinemia. There are a lot of common features between CP and protruded-type MPS. However, it is concluded that both are independent disease entities due to the differences in symptoms, distribution, histological findings and clinical courses including treatment.

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