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Molecular Analysis of the Carcinoma in the Gastro-esophageal Junction Tsuyoshi Noguchi 1 , Masao Chujo 1 , Ryuichi Kikuchi 1 , Yuzo Uchida 1 1The Second Department of Surgery, Oita Medical University Keyword: 食道胃接合部癌 , 分子生物学 , 遺伝子不安定性 , CGH pp.695-702
Published Date 2001/4/25
DOI https://doi.org/10.11477/mf.1403103217
  • Abstract
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 The incidence of gastro-esophageal junction adenocarcinoma has remarkably increased especially in Europe and the USA over the last 20-30 years. Nevertheless, its clinicopathological features and its suitable surgical treatment are still controversial. In this report, we describe the result of our molecular analysis on GEJ carcinomas, Siewert type Ⅰ and Ⅱ.

 From the results of immunohistochemical staining of p53, p16, c-erb-B2, cyclin E and cyclin D1, there were no significant differences in any of the clinicopathological parameters except that the positive rate of cyclin D1 was higher in squamous cell carcinoma than in adenocarcinoma and higher in the protruding type than in the ulcerative type.

 As to the microsatellite analysis, MSI positive rate in GEJ adenocarcinomas is significantly higher than in esophageal squamous cell carcinomas and gastric adenocarcinomas. Finally, it was proved from CGH analysis that the important genes in the carcinogenesis and progression of cancers in this area exsist in 8q, 7q, 13q and so on. These results of CGH analysis are quite different from our results concerning gastric adenocarcinomas.

 From the results of our analysis, the molecular features of GEJ adenocarcinomas might be different from gastric adenocarcinomas. Further research and more cases are needed to elucidate this.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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