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GNAS Mutations in the Tumor-like Lesions and Tumors of the Duodenum Akiko Matsubara 1 , Ryoji Kushima 2 , Haruhisa Suzuki 3 , Ichiro Oda 3 , Hitoshi Tsuda 1 , Shigeki Sekine 4 1Department of Basic Pathology, National Defense Medical College, Tokorozawa, Japan 2Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Japan 3Endoscopy Division, National Cancer Center Hospital, Tokyo 4Pathology Division, National Cancer Center Hospital, Tokyo Keyword: GNAS変異 , 幽門腺腺腫 , 胃腺窩上皮化生 , 異所性胃粘膜 pp.1603-1612
Published Date 2016/11/25
DOI https://doi.org/10.11477/mf.1403200772
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 We analyzed GNAS, KRAS, and BRAF mutations in tumor-like lesions and tumors of the duodenum. We also analyzed clinicopathological findings of the benign tumor-like lesions. GNAS mutations were identified in 41% of GFM(foveolar gastric metaplasia), 28% of GH(gastric heterotopia), 92% of PGA(pyloric gland adenoma), 0% of intestinal-type tubular adenoma, and 17% of adenocarcinoma cases and KRAS mutations were found in 26% of FGM, 2% of GH, 42% of PGA, 20% of intestinal-type tubular adenoma, and 37% of adenocarcinoma cases. A BRAF mutation was found in only one GFM lesion(2%). We performed mutational analysis of the presence of genetic alterations in two epithelial components:foveolar epithelium and oxyntic glands ; we identified similar GNAS mutations in all cases. We further performed immunohistochemical analysis of the 20 adenocarcinoma cases. Adenocarcinoma with GNAS mutations tested significantly positive for MUC5AC and significantly negative for CDX2. Therefore, GFM and GH might be potential precursors of duodenal tumors.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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