Histopathological Examination of Intraepithelial Neoplasia Defined in the New Guide Lines for the Clinical and Pathological Studies on Carcinoma of the Esophagus Yasuo Ohkura 1 1Department of Pathology, Kyorin University School of Medicine, Tokyo Keyword: 食道癌取扱い規約 , 上皮内腫瘍 , 上皮内癌 , 高異型度上皮内腫瘍 , 低異型度上皮内腫瘍 pp.1735-1740
Published Date 2009/10/25
DOI https://doi.org/10.11477/mf.1403101781
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 According to the World Health Organization Classification of Tumours,Pathology and Genetics of Tumours of the Digestive System, intraepithelial neoplasia(IN)of the esophagus was defined in the new guide lines for the clinical and pathological studies on carcinoma of the esophagus. Both definitions are slightly different in the handling of low grade IN. So examined IN histologically, the characteristic and problems of IN are pointed out.

 IN is not benign tumor like adenoma of colorectum and stomach, but atypical epithelium that is doubted cancer. The frequency except of carcinoma in situ(CIS)is around 1%. There are some problems in IN as follows ; 1)the difficulty of morphologic diagnosis of benign tumor, 2)the difficulty of identification of low and high IN and 3)the confusion in diagnosing carcinoma occurred by the removal of CIS from squamous cell carcinoma.

 From the view point that IN is doubted cancer, the diagnostic criteria of CIS is necessary to be established immediately. Then CIS will be diagnosed apart from high grade IN. And IN should be subdivided the degree of doubt cancer, not only by laminar structure of atypical epithelium but also by nuclear atypia.

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