Significance of Endoscopic Evaluation for Small Intestinal Lesion in Patients with Crohn's Disease Hiroshi Nakase 1 , Satoru Ueno 2 , Norimitsu Uza 2 , Tsutomu Chiba 2 , Yoshiharu Sakai 3 1Department of Gastroenterology and Hepatology, Endoscopic Medicine, Kyoto University Hospital, Kyoto, Japan 2Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 3Department of Surgery, Kyoto University Hospital, Kyoto, Japan Keyword: Crohn病 , 小腸病変 , 小腸内視鏡検査 pp.967-974
Published Date 2009/5/25
DOI https://doi.org/10.11477/mf.1403101680
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 Recent studies have suggested that the incidence of Crohn's disease(CD)in Japan is increasing. The development of wireless capsule endoscopy and double balloon endoscopy enables us to investigate small intestinal lesion of patients with CD in detail. In particular, these modalities were very helpful for gastroenterologists not only to diagnose primary lesions of CD but also to evaluate the grade of mucosal healing during medical therapy and to find post-surgical recurrence in CD patients receiving surgical treatment.

 In addition to conventional nutritional therapy, the use of immunomodulators and biologics contributed to the improvement of the quality of life of patients with CD. However, we were unable to observe mucosal healing in small intestinal lesions of patients with CD who had achieved clinical remission, despite these powerful medical therapies. Further study will be necessary to elucidate how to treat small intestinal lesions such as aphtha and erosions, which are endoscopically observed in patients with CD experiencing clinical remission.

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