Prophylactic Effect of Infliximab on Postoperative Recurrence of Small Intestinal Lesions of Crohn's Disease Motohiro Esaki 1 , Takayuki Matsumoto 1 , Shinichiro Yada 1 , Kotaro Ogawa 1 , Kouichi Asano 1 , Tomohiko Moriyama 1 , Atsushi Hirano 1 , Shotaro Nakamura 1 , Hideki Koga 1 , Takashi Ueki 2 , Mitsuo Iida 3 1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Internal Medicine, Kyushu Central Hospital, Fukuoka, Japan Keyword: Crohn病 , インフリキシマブ , 小腸 , 治療 pp.1656-1666
Published Date 2010/9/25
DOI https://doi.org/10.11477/mf.1403102024
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 We retrospectively investigated the prophylactic effect of IFX(infliximab)on postoperative recurrence among 60 patients with CD(Crohn's disease)presenting small intestinal lesions. Of 34 patients who were not administered IFX, 21 patients experienced recurrence during of the follow-up period. On the other hand, only 2 patients showed postoperative recurrence out of 26 patients for whom maintenance IFX treatment was applied. Postoperative follow-up using small intestinal radiography was performed in 13 patients receiving IFX treatment. One patient showed clinical recurrence because of the deterioration of colonic lesions, while his small intestinal lesions were inactive under radiography. Among 12 patients enjoying clinical remission, edematous mucosa with small barium flecks proximal to the ileocolonic anastomosis was detected in one patient under small intestinal radiography, thus indicating radiographic recurrence of CD. No active small intestinal lesion was found in the remaining 11 patients. Considering such favorable clinical and radiographic courses of CD patients undergoing IFX treatment, IFX can be assumed to be a possible maintenance treatment for CD patients after surgery.

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