Characteristic Small Intestinal Lesions in Patients with Amyloidosis Hiroyuki Kobayashi 1 , Takayuki Matsumoto 2 , Shunichi Yanai 2 , Yuji Sakai 1 , Koichi Kurahara 1 , Tadahiko Fuchigami 1 1Institute of Gastroenterology, Matsuyama Red Cross Hospital, Matsuyama, Japan 2Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan Keyword: アミロイドーシス , 十二指腸 , 小腸 , AL型アミロイド , AA型アミロイド pp.687-691
Published Date 2008/4/24
DOI https://doi.org/10.11477/mf.1403101350
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 Radiographic and endoscopic findings of the small intestine concerning which lesion is most frequently the site of amyloid deposit, have revealed considerable differences between amyloid protein type AA and AL. In patients with primary amyloidosis (type AL), there are polypoid protrusions and invariable thickening of the folds, which reflect massive amyloid deposits in the muscularis mucosa, submucosa and muscularis propria. On the other hand, in cases of secondary amyloidosis(type AA), a mucosal pattern with innumerable fine granular elevations is evident, which correlates with expansion of the amyloid deposits in the lamina propria.

 Recently, progression and wider use of double balloon endoscopy and capsule endoscopy enable the diagnosis and treatment of various kinds of small intestine diseases. However, small bowel radiography has been more useful and necessary in cases of diffuse inflammatory diseases in the small intestine such as amyloidosis.

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