Amyloidosis Hiroyuki Eguchi 1 , Shuji Tada 1 , Kenichi Yoshida 1 , Kimitaka Shioya 1 , Masayoshi Uehara 1 , Takahisa Fujimoto 1 , Masatake Muraoka 1 , Yoshihiro Kadono 1 , Takeyasu Kounoe 1 , Mitsuaki Yamamoto 1 , Tetsu Ozaki 1 , Takihiro Kamio 2 1Digestive Disease Center, Saiseikai Kumamoto Hospital, Kumamoto, Japan 2Department of Pathology, Saiseikai Kumamoto Hospital, Kumamoto, Japan Keyword: AAアミロイドーシス , ALアミロイドーシス , 十二指腸 , 小腸 , 微細病変 pp.1005-1012
Published Date 2009/5/25
DOI https://doi.org/10.11477/mf.1403101685
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 Clinicopathologic findings of gastrointestinal tract lesions were investigated in patients with amyloidosis according to the chemical type of amyloid proteins. Endoscopic examination of the gastrointestinal tract revealed considerable differences between amyloid proteins. In cases of AA amyloidosis, there was a coarse mucosal pattern with innumerable fine granular elevations, which correlated with expansion of the lamina propria by amyloid deposits. In cases of AL amyloidosis, there were polypoid protrusions and invariable thickening of the folds, which reflected massive amyloid deposits in the muscularis mucosa, submucosa and muscularis propria. Progression and wider use of capsule endoscopy and double balloon endoscopy will enable detailed diagnosis for amyloidosis from now on. It is important to understand characteristic endoscopic features of amyloidosis for the diagnosis.

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