Celiac Disease Hideyuki Nakazawa 1 , Hideki Makishima 1 , Fumihiro Ishida 1 , Hiroyoshi Ota 2 , Taiji Akamatsu 3 1Department of Internal Medicine, Division of Hematology, Shinshu University School of Medicine, Matsumoto, Japan 2Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicin, Matsumoto, Japan 3Department of Endoscopy, Shinshu University Hospital, Matsumoto, Japan Keyword: セリアック病 , 無グルテン食 , 悪性リンパ腫 , 鉄欠乏性貧血 , 骨粗鬆症 pp.651-655
Published Date 2008/4/24
DOI https://doi.org/10.11477/mf.1403101344
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 Celiac disease is an autoimmune-mediated gastrointestinal disorder, triggered by dietary gluten proteins. Along with the well-known gastrointestinal symptoms of gluten sensitive enteropathy and malnutrition, the extra-gastrointestinal forms of the disease can be identifed;such as iron deficiency anemia, osteoporosis, type Ⅰ diabetes, and cerebellar ataxia. An asymptomatic form of the disease also exists. Patients with celiac disease may carry a long term risk of developing malignant lymphomas, which has encouraged early interventions as a measure based on public health perspectives. The prevalence of the disease in Japan is yet to be clarified, while it is estimated as high as 1% of the population in Europe and North America.

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