Endoscopic Treatment for Metachronous Squamous Cell Cancer―Effect of APC on Multiple tiny Iodine-Unstained Lesions After EMR Hideo Shimada 1 , Hiroyasu Makuuchi 1 , Osamu Chino 1 , Takayuki Nishi 1 , Yoshifumi Kise 1 , Tomoko Hanashi 1 , Takahiro Kenmochi 1 , Soichiro Yamomoto 1 , Tadai Hara 1 1Department of Surgery, Tokai University, School of Medicine, Kanagawa, Japan Keyword: 異時性多発食道癌 , EMR , APC , 多発ヨード不染 , 食道メインテナンス pp.1381-1388
Published Date 2007/8/25
DOI https://doi.org/10.11477/mf.1403101177
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 Development of endoscopic resection and its larger indication for use in superficial esophageal cancer enabled the preservation of the esophagus and improvement of quality of life after the treatment. On the other hand, the field cancerization in the preserved organ remains. We are encountering increasing opportunities to find multiple cancer lesions and metachronous squamous cell cancer through the use of iodine staining during endoscopic examination. We performed APC on 71 patients with multiple tiny iodine-unstained lesions after EMR, including 19.7% of squamous cell cancers and 43.7% of dysplasia. The unstained lesions disappeared after APC in 64.4% of the treated cases. Of the 16 cases resistant to the APC treatment, 10 cases were shown by biopsy to be squamous cell carcinomas and EMR was performed again. APC is simple and considered to be effective in multiple tiny iodine-unstained lesions of the esophageal mucosa.

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