Multiple Early Esophageal Cancer Treated with Endoscopic Mucosal Resection (EMR) Hiroyasu Makuuchi 1 , Hideo Shimada 1 , Osamu Chino 1 , Yoshihumi Kise 1 1Department of Surgery, Tokai University, School of Medicine Keyword: 多発食道癌 , 早期食道癌 , ヨード染色 , 重複癌 , 内視鏡的粘膜切除術 pp.1027-1038
Published Date 2001/7/25
DOI https://doi.org/10.11477/mf.1403103276
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 Seventy-two multiple primary esophageal cancers were analyzed from 349 cases of early esophageal cancer treated by endoscopic mucosal resection. In those patients, the differentiation between solitary and multiple lesions was possible, and asynchronous multiple lesions could be detected by long-term follow up. Multiple cancers consisted of 51 cases of synchronous and 28 cases of asynchronous ones. Multiple cases amounted to 85 cases (24.4%) when dysplasia is counted as a cancerous lesion. The characteristics of synchronous multiple cancers were: 1) The most frequent number of lesions was 2 (70.6%). 2) The most frequent type was 0-Ⅱ type, which was mostly m1 or m2 in depth (90.2%). The characteristics of the asynchronous multiple cancers were: 1) Asynchronous cancers occupied 8% of all the endoscopic mucosal resection cases. 2) The mean interval between the first lesion and the appearance of the second lesion was 2 and a half years. The multiple primary lesions had a significantly greater number of asynchronous lesions than the solitary primary lesions. Careful follow-up is required even in the dysplasia cases diagnosed by biopsy or endoscopic mucosal resection. A cancer is generally developing in a multiple manner, so the possibility of double cancers should be always kept in mind as a reason for follow-up after detection of a sole cancer.

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