Long-time Follow-up Study of Localized Gastric Mucosa-associated Lymphoid Tissue(MALT)Lymphoma and the Clinical Features of Antibiotic-resistant Cases of Gastric MALT Lymphoma Taiji Akamatsu 1 , Ken-ichi Suzawa 2 , Yasunori Kaneko 2 , Hideharu Miyabayashi 3 , Naoto Shikama 4 , Kenji Sano 5 , Hiroyoshi Ota 6 1Department of Endoscopy, Shinshu University Hospital, Matsumoto, Japan 2Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan 3Internal Medicine, National Hospital Organization, Matsumoto Hospital, Matsumoto, Japan 4Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan 5Clinical Laboratories, Shinshu University Hospital, Matsumoto, Japan 6Department of Biomedical Sciences, School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Japan Keyword: 胃MALTリンパ腫 , Helicobacter pylori , 除菌療法 , 放射線療法 , 長期経過 pp.1207-1216
Published Date 2007/7/25
DOI https://doi.org/10.11477/mf.1403101152
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 To clarify the clinical features of gastric MALT lymphoma(GML)with persistent lymphoma after eradication therapy of Helicobacter pylori(H. pylori), and the outcome of long-time follow-up study after treatment against GML, seventy-six patients with localized GML were studied. The median follow-up period was 44.4 months. Thirty-eight of 49 patients(77.6%)with H. pylori-positive GML had been cured of GML by antibiotic therapy alone. On the other hand, none of 13 patients with H. pylori-negative GML had been cured by antibiotic therapy(77.6%vs 0%, p<0.001)."H. pylori-negative"is one of the clinical features of antibiotic-resistant cases with GML. There was no significant difference in sex, age, stage, endoscopic finding, depth, and affected region between the two groups of cured and persistent GML with H. pylori infection. Twenty-two of 29 patients(75.6%)with antibiotic-resistant or H. pylori-negative cases of GML had been cured by 30 Gy radiation therapy. Low-dose radiation was thought to be a useful therapeutic procedure as a"second line treatment"of localized GML.

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