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Pathological Diagnosis of Serrated Lesion of the Colorectum Yoichi Ajioka 1 , Asako Takamura 1 , Ken Nishikura 1 , Gen Watanabe 1 1Division of Molecular and Diagnostic Pathology, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan Keyword: 鋸歯状病変 , 鋸歯状腺腫 , 異型過形成性ポリープ , 過形成性ポリープ , 組織診断基準 pp.253-260
Published Date 2007/3/25
DOI https://doi.org/10.11477/mf.1403100961
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 We classify serrated lesion of the colorectum into serrated adenoma (SA), hyperplastic polyp (HP), and atypical hyperplastic polyp (AHP), according to the combination of the major (nuclear pseudostratification in the middle to the upper zone of the crypt) and two minor findings (eosinophilic cytoplasm and glandular branching). Both nuclear pseudostratification and glandular branching reflect the abnormal proliferation and eosinophilic cytoplasm reflect goblet cell immature differentiation. In western countries, serrated lesions are put together as serrated polyp and classified into hyperplastic polyp (HP), sessile serrated adenoma (SSA), and traditional serrated adenoma (TSA), which correspond to the HP, AHP, and SA of our classification, respectively. It is thought most important to elucidate the nature of AHP (or SSA), whether neoplastic or not, for the pathological diagnosis of serrated lesion.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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