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Histologic Criteria for Serrated Adenoma Masahiro Ikegami 1 , Shoichi Saitou 2 , Hiroshi Hano 1 1Department of Pathology, The Jikei University School of Medicine, Tokyo 2Department of Endoscopy, The Jikei University School of Medicine, Tokyo Keyword: serrated adenoma , hyperplastic polyp , MIB-1 index , histology pp.261-265
Published Date 2007/3/25
DOI https://doi.org/10.11477/mf.1403100962
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 We studied the histological features of serrated adenoma which, according to Longacre et al., are suitable as pathological diagnostic criteria.

 Ninety-three lesions of serrated adenoma obtained by colonoscopy were studied. As control, 170 hyperplastic polyps and 100 tubular adenomas were used.

 Proliferating cells in serrated adenoma frequently moved from the base of the crypt to the upper portion, as revealed by Ki-67 (MIB-1) stain. The result obtained in this study suggests that serrated adenoma has neoplastic characteristics similar to tubular adenoma and nuclear pseudostratification of the crypt from the middle to the upper zone, which features have high predictive value for diagnosing serrated adenoma.


Copyright © 2007, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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